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The principal cytochrome P450 isoenzyme involved seems to become CYP2E1, with CYP1A2 and CYP3A4 as more pathways. Roughly eighty five% of an oral dose appears within the urine in just 24 several hours of administration, most because the glucuronide conjugate, with small quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity